Expertise Medicinal Chemistry
- Evaluation of targets
- Evaluation of hits from screening or otherwise identified
- Evaluation of leads
- Provide guidance in hit and lead optimization
- Hands on experience; lead-2-development candidate optimization following medicinal chemistry based concepts especially focused on parallel optimization of potency, selectivity, solubility, metabolic stability, permeability, bioavailability, safety, chemical stability; supporting design of NCE’s (experience with modeling programs such as Benchware 3D explorer, Accelrys Discovery Studio and Yasara).
- Setting up synthesis schemes towards dedicated compounds
- Designing compounds and/or focused libraries for hit/ lead optimization
- Monitoring the quality and progress of your project especially in respect to medicinal chemistry related issues following/implementing state-of-the art knowhow, technologies and expertise’s.
- Designing focused ligand or structure based libraries for different target families
- Project management of hit-2-lead and lead-2-DC projects
- Providing support in identifying the ideal Contract Research Organization (CRO) for your project
- Provide support in setting up contract and/or managing CRO-based research
- Providing training on topics related to early stages in drug discovery